We used this information to define the proportion of clonal cells and genetic architecture at the time of medical diagnosis of a myelodysplastic syndrome and progression to secondary AML. Methods Methods are described in detail in the Supplementary Appendix, available with the entire text of this article at NEJM.org. In brief, bone marrow biopsy specimens had been obtained from seven topics, all of whom provided written informed consent on a form that contained specific language authorizing whole-genome sequencing.Remission was defined as a Mayo rating of < 2 and no individual subscore > 1. The Mayo rating is calculated predicated on subscores of stool rate of recurrence, rectal bleeding, physician’s global evaluation and endoscopy. In the FDA-approved dose, both studies achieved their major endpoints. The safety results from both studies were consistent with the known safety profile of HUMIRA no new safety indicators were identified. About Abbott Abbott is definitely a global, broad-based health care company specialized in the discovery, development, marketing and produce of pharmaceuticals and medical items, including nutritionals, devices and diagnostics.