Cells then safely switch into energy saving mode until plentiful situations return. Previously, Shaw and others had shown that although AMPK performs a crucial growth-slowing function, it requires its orders from a biochemical big boss, the proteins LKB1. LKB1 is usually a so-called tumor-suppressor, and therefore its loss correlates with development of benign growths, known as hamartomas, plus some types of malignant lung and colon cancer. Once growth-regulating LKB1 was out of the picture, several tumors demonstrated very high degrees of unregulated mTOR activity.The circumsporozoite protein SERA-2 and C-terminal amplicons were sequenced on an Illumina MiSeq platform. All MiSeq and PacBio amplicon sequence data were submitted to the NCBI Sequence Browse Archive35 . Study Oversight The trial was sponsored by GlaxoSmithKline Biologicals, the developer and producer of the vaccine, and was funded by both GlaxoSmithKline Biologicals and the road Malaria Vaccine Initiative, which received a grant from the Melinda and Expenses Gates Foundation. Many of the academic authors, in collaboration with the four authors who have employment with GlaxoSmithKline Biologicals, designed the scholarly study and the analysis program.