Sam Schulman, M.D http://priligyfr.com/#contactez ., Clive Kearon, M.D., Ajay K. Kakkar, M.D., Patrick Mismetti, M.D., Sebastian Schellong, M.D., Henry Eriksson, M.D., David Baanstra, M.Sc., Janet Schnee, M.D., and Samuel Z. Goldhaber, M.D. For the RE-COVER Study Group: Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism Venous thromboembolism affects one to two 2 adults per 1000 annually and is the third most common reason behind vascular death after myocardial infarction and stroke.1,2 The existing regular treatment is rapidly acting parenteral anticoagulation for 5 to seven days followed by at least 3 months of treatment with a vitamin K antagonist.3 Treatment with a vitamin K antagonist requires frequent monitoring of the worldwide normalized ratio , and multiple interactions of vitamin K antagonists with foods and various other drugs have already been reported.4 Dabigatran etexilate can be an orally obtainable, potent, direct inhibitor of thrombin.
In analyses involving females who became pregnant, live-birth rates also didn’t differ considerably among the three groups, with rates of 69.1 percent in the combination-therapy group, 61.6 percent in the aspirin-only group, and 67.0 percent in the placebo group . In a post hoc per-protocol analysis taking into account adherence to the designated study drug, live-birth prices were nearly the same as those in the intention-to-treat analysis . Simply no significant differences in secondary outcomes were observed among the three groups, except that ladies in the combination-therapy group delivered approximately a week earlier than women in the placebo group . An increased inclination to bruise and swelling or itching at the injection site had been significantly more common in women in the combination-therapy group than in those in the placebo group.