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A complete of 99,571 individuals had been exposed to natalizumab, representing 209,123 patient-years of encounter . The risk of PML increased with raising duration of treatment, with the greatest increase in risk happening after 24 months of therapy Connected with Natalizumab Therapy, According to Duration of Treatment in 12-Month Intervals.). Data beyond 4 years of therapy were limited. Prior Immunosuppressant Make use of as a Risk Element for PML The usage of immunosuppressants prior to the initiation of natalizumab therapy was more prevalent among patients in whom PML subsequently developed than among patients enrolled in the TYGRIS study, which represented the overall patient population receiving natalizumab therapy.