Buller, M.D., Ph.D., Alexander Cohen, M.D., Madelyn Curto, D.V.M., Alexander S. Gallus, M.D., Margot Johnson, M.D., Urszula Masiukiewicz, M.D., Raphael Pak, Ph.D., John Thompson, Ph.D., Gary E. Raskob, Ph.D., and Jeffrey I. Weitz, M.D. For the AMPLIFY Investigators: Oral Apixaban for the Treatment of Acute Venous Thromboembolism Venous thromboembolism, with an annual incidence of 1 1 to 2 2 cases per 1000 persons in the overall population, may be the third most common cause of vascular death after myocardial infarction and stroke.1 Conventional treatment consists of a parenteral anticoagulant, such as enoxaparin, for at least 5 days, and warfarin begun in this right time and continued for at least 3 months.2 Although effective, this presents a problem because enoxaparin requires daily subcutaneous injections regimen, and warfarin therapy requires coagulation dose and monitoring adjustment.There’s also been a notable uptick in happy teens. In the 1970s, for example, 19 % of 12th graders chose that response, compared with 23 % in the 2010s. Millennials admit smartphones are sapping their happinessAdults age group 30 and older, nevertheless, have seen a five-%age-point drop, today from 38 % in the early 1970s to 33 %. The results – which are from University of Chicago’s longstanding General Public Survey and the University of Michigan’s Monitoring the Future survey – ring accurate for Emily Valdez, a 49-year-old mom in Seattle. I believed that life would be simpler, she says. My parents’ marriage, kids, child-rearing. Just seemed – and seems in their eyes – much less fraught with indecision still, second-guessing and only less insecurity maybe. Some state the onslaught of information at our fingertips every day is one aspect making us experience overwhelmed.