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Acute manic episodes associated with increased edema risk By Lucy Piper, Senior medwireNews Reporter Bipolar disorder patients admitted to medical center with a manic event are at an increased risk for lower limb edema , weighed against their peers with depressive or non-affective psychosis episodes, study findings show. The full total results suggest a feasible causal relationship between feeling and fluid imbalance, says the united team, and a feasible role for LLE as a surrogate physical marker for severe manic exacerbation.